Randomized Controlled Trial to Compare the Safety and Efficacy of Tamsulosin, Solifenacin, and Combination of Both in Treatment of Double-J Stent-Related Lower Urinary Symptoms
Joint Authors
Shalaby, Essam
Maarouf, Aref
Yahia, Iman
Ahmed, Abul-fotouh
Ghobish, Ammar
Ali, Mohamed
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
We evaluated the effectiveness and safety of tamsulosin, solifenacin, and combination of both in reducing double-J stent-related lower urinary symptoms.
Materials and Methods.
A total of 338 patients with double-J ureteral stenting were randomly divided, postoperatively, into 4 groups.
In group I (n=84), no treatment was given (control group), group II (n=85) received tamsulosin 0.4 mg daily, group III (n=84) received solifenacin 10 mg daily, and group IV (n=85) received a combination of both medications.
Before insertion and 2 weeks after, all patients completed the International Prostate Symptom Score (IPSS), quality of life component of the IPSS (IPSS/Qol), Overactive Bladder Questionnaire (OAB-q), and Visual Analogue Pain Scale (VAPS) questionnaire.
Results.
The demographics and preoperative questionnaires scores of all groups were comparable.
There were statistically significant differences in all scores in favour of groups II, III, and IV as compared to control group (P value < 0.005).
Group IV showed statistically significant differences in total IPSS, QoL score, and OAB-q score as compared to groups II and III (P value < 0.001).
Conclusions.
Combined therapy of tamsulosin and solifenacin significantly alleviated lower urinary symptoms associated with double-J stents as compared to either medication alone.
American Psychological Association (APA)
Shalaby, Essam& Ahmed, Abul-fotouh& Maarouf, Aref& Yahia, Iman& Ali, Mohamed& Ghobish, Ammar. 2013. Randomized Controlled Trial to Compare the Safety and Efficacy of Tamsulosin, Solifenacin, and Combination of Both in Treatment of Double-J Stent-Related Lower Urinary Symptoms. Advances in Urology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-495937
Modern Language Association (MLA)
Shalaby, Essam…[et al.]. Randomized Controlled Trial to Compare the Safety and Efficacy of Tamsulosin, Solifenacin, and Combination of Both in Treatment of Double-J Stent-Related Lower Urinary Symptoms. Advances in Urology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-495937
American Medical Association (AMA)
Shalaby, Essam& Ahmed, Abul-fotouh& Maarouf, Aref& Yahia, Iman& Ali, Mohamed& Ghobish, Ammar. Randomized Controlled Trial to Compare the Safety and Efficacy of Tamsulosin, Solifenacin, and Combination of Both in Treatment of Double-J Stent-Related Lower Urinary Symptoms. Advances in Urology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-495937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495937