Roles of PI3KAKTGSK3mTOR Pathway in Cell Signaling of Mental Illnesses
Joint Authors
Kobayashi, Mayumi
Kikuta, Kanae
Matsuda, Satoru
Kitagishi, Yasuko
Source
Depression Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Several pharmacological agents acting on monoamine neurotransmission are used for the management of mental illnesses.
Regulation of PI3K/AKT and GSK3 pathways may constitute an important signaling center in the subcellular integration of the synaptic neurotransmission.
The pathways also modulate neuronal cell proliferation, migration, and plasticity.
There are evidences to suggest that inflammation of neuron contributes to the pathology of depression.
Inflammatory activation of neuron contributes to the loss of glial elements, which are consistent with pathological findings characterizing the depression.
A mechanism of anti-inflammatory reactions from antidepressant medications has been found to be associated with an enhancement of heme oxygenase-1 expression.
This induction in brain is also important in neuroprotection and neuroplasticity.
As enzymes involved in cell survival and neuroplasticity are relevant to neurotrophic factor dysregulation, the PI3K/AKT/GSK3 may provide an important signaling for the neuroprotection in depression.
In this paper, we summarize advances on the involvement of the PI3K/AKT/GSK3 pathways in cell signaling of neuronal cells in mental illnesses.
American Psychological Association (APA)
Kitagishi, Yasuko& Kobayashi, Mayumi& Kikuta, Kanae& Matsuda, Satoru. 2012. Roles of PI3KAKTGSK3mTOR Pathway in Cell Signaling of Mental Illnesses. Depression Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-495957
Modern Language Association (MLA)
Kitagishi, Yasuko…[et al.]. Roles of PI3KAKTGSK3mTOR Pathway in Cell Signaling of Mental Illnesses. Depression Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-495957
American Medical Association (AMA)
Kitagishi, Yasuko& Kobayashi, Mayumi& Kikuta, Kanae& Matsuda, Satoru. Roles of PI3KAKTGSK3mTOR Pathway in Cell Signaling of Mental Illnesses. Depression Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-495957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495957