Simulators of Squamous Cell Carcinoma of the Skin : Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation
Joint Authors
Lee, Yoke-Sun
Lee, Shu-Jin
Aw, Derrick Chen-Wee
Tan, Kong-Bing
Jaffar, Huma
Lim, Thiam-Chye
Tan, Sze-Hwa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Squamous cell carcinoma (SCC) is a common and important primary cutaneous malignancy.
On skin biopsies, SCC is characterized by significant squamous cell atypia, abnormal keratinization, and invasive features.
Diagnostic challenges may occasionally arise, especially in the setting of small punch biopsies or superficial shave biopsies, where only part of the lesion may be assessable by the pathologist.
Benign mimics of SCC include pseudoepitheliomatous hyperplasia, eccrine squamous syringometaplasia, inverted follicular keratosis, and keratoacanthoma, while malignant mimics of SCC include basal cell carcinoma, melanoma, and metastatic carcinoma.
The careful application of time-honored diagnostic criteria, close clinicopathological correlation and a selective request for a further, deeper, or wider biopsy remain the most useful strategies to clinch the correct diagnosis.
This review aims to present the key differential diagnoses of SCC, to discuss common diagnostic pitfalls, and to recommend ways to deal with diagnostically challenging cases.
American Psychological Association (APA)
Tan, Kong-Bing& Tan, Sze-Hwa& Aw, Derrick Chen-Wee& Jaffar, Huma& Lim, Thiam-Chye& Lee, Shu-Jin…[et al.]. 2013. Simulators of Squamous Cell Carcinoma of the Skin : Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation. Journal of Skin Cancer،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495987
Modern Language Association (MLA)
Tan, Kong-Bing…[et al.]. Simulators of Squamous Cell Carcinoma of the Skin : Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation. Journal of Skin Cancer No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-495987
American Medical Association (AMA)
Tan, Kong-Bing& Tan, Sze-Hwa& Aw, Derrick Chen-Wee& Jaffar, Huma& Lim, Thiam-Chye& Lee, Shu-Jin…[et al.]. Simulators of Squamous Cell Carcinoma of the Skin : Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation. Journal of Skin Cancer. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495987