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Lysosomal Fusion Dysfunction as a Unifying Hypothesis for Alzheimer's Disease Pathology
Joint Authors
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Alzheimer's disease is characterized pathologically by extracellular senile plaques, intracellular neurofibrillary tangles, and granulovacuolar degeneration.
It has been debated whether these hallmark lesions are markers or mediators of disease progression, and numerous paradigms have been proposed to explain the appearance of each lesion individually.
However, the unfaltering predictability of these lesions suggests a single pathological nidus central to disease onset and progression.
One of the earliest pathologies observed in Alzheimer's disease is endocytic dysfunction.
Here we review the recent literature of endocytic dysfunction with particular focus on disrupted lysosomal fusion and propose it as a unifying hypothesis for the three most-studied lesions of Alzheimer's disease.
American Psychological Association (APA)
Funk, Kristen E.& Kuret, Jeff. 2012. Lysosomal Fusion Dysfunction as a Unifying Hypothesis for Alzheimer's Disease Pathology. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495991
Modern Language Association (MLA)
Funk, Kristen E.& Kuret, Jeff. Lysosomal Fusion Dysfunction as a Unifying Hypothesis for Alzheimer's Disease Pathology. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-495991
American Medical Association (AMA)
Funk, Kristen E.& Kuret, Jeff. Lysosomal Fusion Dysfunction as a Unifying Hypothesis for Alzheimer's Disease Pathology. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495991
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495991