Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation
Joint Authors
Lam, Nicholas C. K.
Cattano, Davide
Hagberg, Carin A.
Wilcox, Darrell W.
Ferrario, Lara
Seitan, Carmen
Vahdat, Kash
Source
Anesthesiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study compared remifentanil and dexmedetomidine as awake fiberoptic intubation (AFOI) anesthetics.
Thirty-four adult ASA I-III patients were enrolled in a double-blinded randomized pilot study to receive remifentanil (REM) or dexmedetomidine (DEX) for sedation during AFOI (nasal and oral).
Thirty patients completed the study and received 2 mg midazolam IV and topical anesthesia.
The REM group received a loading dose of 0.75 mcg/kg followed by an infusion of 0.075 mcg/kg/min.
The DEX group received a loading dose of 0.4 mcg/kg followed by an infusion of 0.7 mcg/kg/hr.
Time to sedation, number of intubation attempts, Ramsay sedation scale (RSS) score, bispectral index (BIS), and memory recall were recorded.
All thirty patients were successfully intubated by AFOI (22 oral intubations/8 nasal).
First attempt success rate with AFOI was higher in the REM group than the DEX group, 72% and 38% (P=0.02), respectively.
The DEX group took longer to attain RSS of ≥3 and to achieve BIS <80, as compared to the REM group.
Postloading dose verbal recall was poorer in the DEX group.
Dexmedetomidine seems a useful adjunct for patients undergoing AFOI but is dependent on dosage and time.
Further studies in the use of dexmedetomidine for AFOI are warranted.
American Psychological Association (APA)
Cattano, Davide& Lam, Nicholas C. K.& Ferrario, Lara& Seitan, Carmen& Vahdat, Kash& Wilcox, Darrell W.…[et al.]. 2012. Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation. Anesthesiology Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-496022
Modern Language Association (MLA)
Cattano, Davide…[et al.]. Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation. Anesthesiology Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-496022
American Medical Association (AMA)
Cattano, Davide& Lam, Nicholas C. K.& Ferrario, Lara& Seitan, Carmen& Vahdat, Kash& Wilcox, Darrell W.…[et al.]. Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation. Anesthesiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-496022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496022