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The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease
Joint Authors
Fontenelle, Leonardo F.
Lauterbach, Edward C.
Teixeira, Antonio Lucio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Neuroprotective treatments in Parkinson's disease (PD) have remained elusive.
Psychotropics are commonly prescribed in PD without regard to their pathobiological effects.
The authors investigated the effects of psychotropics on pathobiological proteins, proteasomal activity, mitochondrial functions, apoptosis, neuroinflammation, trophic factors, stem cells, and neurogenesis.
Only findings replicated in at least 2 studies were considered for these actions.
Additionally, PD-related gene transcription, animal model, and human neuroprotective clinical trial data were reviewed.
Results indicate that, from a PD pathobiology perspective, the safest drugs (i.e., drugs least likely to promote cellular neurodegenerative mechanisms balanced against their likelihood of promoting neuroprotective mechanisms) include pramipexole, valproate, lithium, desipramine, escitalopram, and dextromethorphan.
Fluoxetine favorably affects transcription of multiple genes (e.g., MAPT, GBA, CCDC62, HIP1R), although it and desipramine reduced MPTP mouse survival.
Haloperidol is best avoided.
The most promising neuroprotective investigative priorities will involve disease-modifying trials of the safest agents alone or in combination to capture salutary effects on H3 histone deacetylase, gene transcription, glycogen synthase kinase-3, α-synuclein, reactive oxygen species (ROS), reactive nitrogen species (RNS), apoptosis, inflammation, and trophic factors including GDNF and BDNF.
American Psychological Association (APA)
Lauterbach, Edward C.& Fontenelle, Leonardo F.& Teixeira, Antonio Lucio. 2011. The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease. Journal of Ophthalmology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-496060
Modern Language Association (MLA)
Lauterbach, Edward C.…[et al.]. The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease. Journal of Ophthalmology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-496060
American Medical Association (AMA)
Lauterbach, Edward C.& Fontenelle, Leonardo F.& Teixeira, Antonio Lucio. The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease. Journal of Ophthalmology. 2011. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-496060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496060