Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain

Joint Authors

Chen, Gang
Berta, Temugin
Taves, Sarah
Ji, Ru-Rong

Source

Neural Plasticity

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-08-18

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Microglia are regarded as macrophages in the central nervous system (CNS) and play an important role in neuroinflammation in the CNS.

Microglial activation has been strongly implicated in neurodegeneration in the brain.

Increasing evidence also suggests an important role of spinal cord microglia in the genesis of persistent pain, by releasing the proinflammatory cytokines tumor necrosis factor-alpha (TNFα), Interleukine-1beta (IL-1β), and brain derived neurotrophic factor (BDNF).

In this review, we discuss the recent findings illustrating the importance of microglial mediators in regulating synaptic plasticity of the excitatory and inhibitory pain circuits in the spinal cord, leading to enhanced pain states.

Insights into microglial-neuronal interactions in the spinal cord dorsal horn will not only further our understanding of neural plasticity but may also lead to novel therapeutics for chronic pain management.

American Psychological Association (APA)

Taves, Sarah& Berta, Temugin& Chen, Gang& Ji, Ru-Rong. 2013. Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain. Neural Plasticity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496070

Modern Language Association (MLA)

Taves, Sarah…[et al.]. Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain. Neural Plasticity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-496070

American Medical Association (AMA)

Taves, Sarah& Berta, Temugin& Chen, Gang& Ji, Ru-Rong. Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496070

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-496070