Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain
Joint Authors
Chen, Gang
Berta, Temugin
Taves, Sarah
Ji, Ru-Rong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Microglia are regarded as macrophages in the central nervous system (CNS) and play an important role in neuroinflammation in the CNS.
Microglial activation has been strongly implicated in neurodegeneration in the brain.
Increasing evidence also suggests an important role of spinal cord microglia in the genesis of persistent pain, by releasing the proinflammatory cytokines tumor necrosis factor-alpha (TNFα), Interleukine-1beta (IL-1β), and brain derived neurotrophic factor (BDNF).
In this review, we discuss the recent findings illustrating the importance of microglial mediators in regulating synaptic plasticity of the excitatory and inhibitory pain circuits in the spinal cord, leading to enhanced pain states.
Insights into microglial-neuronal interactions in the spinal cord dorsal horn will not only further our understanding of neural plasticity but may also lead to novel therapeutics for chronic pain management.
American Psychological Association (APA)
Taves, Sarah& Berta, Temugin& Chen, Gang& Ji, Ru-Rong. 2013. Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain. Neural Plasticity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496070
Modern Language Association (MLA)
Taves, Sarah…[et al.]. Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain. Neural Plasticity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-496070
American Medical Association (AMA)
Taves, Sarah& Berta, Temugin& Chen, Gang& Ji, Ru-Rong. Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496070