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Titin Diversity—Alternative Splicing Gone Wild
Joint Authors
Guo, Wei
Greaser, Marion L.
Esbona, Karla
Bharmal, Sheila J.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Titin is an extremely large protein found in highest concentrations in heart and skeletal muscle.
The single mammalian gene is expressed in multiple isoforms as a result of alternative splicing.
Although titin isoform expression is controlled developmentally and in a tissue specific manner, the vast number of potential splicing pathways far exceeds those described in any other alternatively spliced gene.
Over 1 million human splice pathways for a single individual can be potentially derived from the PEVK region alone.
A new splicing pattern for the human cardiac N2BA isoform type has been found in which the PEVK region includes only the N2B type exons.
The alterations in splicing and titin isoform expression in human heart disease provide impetus for future detailed study of the splicing mechanisms for this giant protein.
American Psychological Association (APA)
Guo, Wei& Bharmal, Sheila J.& Esbona, Karla& Greaser, Marion L.. 2010. Titin Diversity—Alternative Splicing Gone Wild. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-496071
Modern Language Association (MLA)
Guo, Wei…[et al.]. Titin Diversity—Alternative Splicing Gone Wild. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-496071
American Medical Association (AMA)
Guo, Wei& Bharmal, Sheila J.& Esbona, Karla& Greaser, Marion L.. Titin Diversity—Alternative Splicing Gone Wild. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-496071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496071