Monocyte Function in the Fetus and the Preterm Neonate : Immaturity Combined with Functional Impairment
Joint Authors
Siristatidis, Charalampos
Pappa, Kalliopi I.
Anastasiadis, Anastasis
Varras, Michail
Zoe, Iliodromiti
Vrachnis, Nicolaos
Bakoulas, Vassilios
Mastorakos, George
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
It is well known that the innate immunity system, involving the contribution of monocytes and macrophages, may dysfunction in fetuses and preterm neonates.
Monocytes are capable of differentiating into dendritic cells (DCs) or into mucosal macrophages during certain infections and of producing inflammatory mediators such as TNF-α (tumor necrosis factor-alpha), nitric oxide, and reactive oxygen species.
Fetuses as well as neonates are prone to infections as a result of a defective mechanism within the above mononuclear system.
Monocyte function in fetuses and preterm neonates depends on the phagocytic and oxidative capacity of macrophages and their antigen-adhesion ability.
Functional rather than anatomical impairment is probably the underlying cause, while a defective production of cytokines, such as TNF-α, IL-6 (Interleukin 6), IL-1β (Interleukin 1 beta), and G-CSF (Granulocyte Colony-Stimulating Factor), has also been involved.
The insufficient production of the above inflammatory mediators and the phenomenon of endotoxin intolerance, which latter occurs during entry of any antigen into the premature neonate, place preterm neonates at higher risk for infections.
Existing research data are herein presented which, however, are deficient and fragmental, this accounting for the fact that the precise pathophysiology of these disturbances is not yet fully clarified.
American Psychological Association (APA)
Zoe, Iliodromiti& Anastasiadis, Anastasis& Varras, Michail& Pappa, Kalliopi I.& Siristatidis, Charalampos& Bakoulas, Vassilios…[et al.]. 2013. Monocyte Function in the Fetus and the Preterm Neonate : Immaturity Combined with Functional Impairment. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-496082
Modern Language Association (MLA)
Zoe, Iliodromiti…[et al.]. Monocyte Function in the Fetus and the Preterm Neonate : Immaturity Combined with Functional Impairment. Mediators of Inflammation No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-496082
American Medical Association (AMA)
Zoe, Iliodromiti& Anastasiadis, Anastasis& Varras, Michail& Pappa, Kalliopi I.& Siristatidis, Charalampos& Bakoulas, Vassilios…[et al.]. Monocyte Function in the Fetus and the Preterm Neonate : Immaturity Combined with Functional Impairment. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-496082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496082