Association between Circulating Endothelial Cells and Carotid Atherosclerosis in Patients Receiving Maintenance Hemodialysis
Joint Authors
Hui-lan, Liu
Kun-ying, Zhang
Xiao-feng, Duan
Guo-gang, Li
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Accelerated atherosclerosis is the major cause of mortality in maintenance hemodialysis (MHD) patients, and endothelial injury associated with MHD might contribute strongly to pathogenesis.
The current study was designed to explore possible associations between circulating endothelial cells (CECs) and intima-media thickness of common carotid artery (CCA-IMT) as an indicator of carotid atherosclerosis.
Sixty-two MHD patients and 26 age- and sex-matched healthy volunteers were recruited.
The number of CECs was determined in peripheral blood using multiparametric flow cytometry.
CCA-IMT and presence of plaques in the common carotid arteries were assessed with ultrasound.
Laboratory tests results and the demographics were recorded.
The finding indicated that numbers of CECs were higher in patients before hemodialysis (predialysis) compared with numbers in controls (P = 0.045).
CCA-IMT was also significantly higher in patients than in controls (P < 0.01).
A positive relationship was observed between predialysis CECs numbers and CCA-IMT (P < 0.01) in MHD patients.
In multiple linear regression analysis, the relationship between the predialysis CECs level and CCA-IMT remained the same even if adjusting for confounding effects.
Accordingly, the investigation indicates that the CECs level is positively associated with CCA-IMT in our hemodialysis patients.
CECs might be an important marker to the severity of carotid atherosclerosis in MHD patients.
American Psychological Association (APA)
Kun-ying, Zhang& Hui-lan, Liu& Xiao-feng, Duan& Guo-gang, Li. 2014. Association between Circulating Endothelial Cells and Carotid Atherosclerosis in Patients Receiving Maintenance Hemodialysis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-496084
Modern Language Association (MLA)
Kun-ying, Zhang…[et al.]. Association between Circulating Endothelial Cells and Carotid Atherosclerosis in Patients Receiving Maintenance Hemodialysis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-496084
American Medical Association (AMA)
Kun-ying, Zhang& Hui-lan, Liu& Xiao-feng, Duan& Guo-gang, Li. Association between Circulating Endothelial Cells and Carotid Atherosclerosis in Patients Receiving Maintenance Hemodialysis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-496084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496084