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Effects of Low Level Laser Therapy on Ovalbumin-Induced Mouse Model of Allergic Rhinitis
Joint Authors
Choi, Binhye
Park, Jae-Woo
Ryu, Bongha
Kim, Ha Young
Kim, Jinsung
Chang, Mun Seog
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
This study was designed to investigate the effects of low level laser therapy (LLLT) on experimental allergic rhinitis (AR) models induced by ovalbumin.
Materials and Methods.
AR was induced by 1% ovalbumin in mice.
Twenty-four mice were divided into 4 groups: normal, control, low, and high dose irradiation.
Low and high dose LLLT were irradiated once a day for 7 days.
Total IgE, cytokines concentrations (IL-4 and IFN-γ), and thymus and activation regulated chemokine (TARC) were measured.
Histological changes in the nasal mucosal tissue by laser irradiation were examined.
Results.
LLLT significantly inhibited total IgE, IL-4, and TARC expression in ovalbumin-induced mice at low dose irradiation.
The protein expression level of IL-4 in spleen was inhibited in low dose irradiation significantly.
IL-4 expression in EL-4 cells was inhibited in a dose dependent manner.
Histological damages of the epithelium in the nasal septum were improved by laser irradiation with marked improvement at low dose irradiation.
Conclusion.
These results suggest that LLLT might serve as a new therapeutic tool in the treatment of AR with more effectiveness at low dose irradiation.
To determine the optimal dose of laser irradiation and action mechanisms of laser therapy, further studies will be needed.
American Psychological Association (APA)
Choi, Binhye& Chang, Mun Seog& Kim, Ha Young& Park, Jae-Woo& Ryu, Bongha& Kim, Jinsung. 2013. Effects of Low Level Laser Therapy on Ovalbumin-Induced Mouse Model of Allergic Rhinitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-496088
Modern Language Association (MLA)
Park, Jae-Woo…[et al.]. Effects of Low Level Laser Therapy on Ovalbumin-Induced Mouse Model of Allergic Rhinitis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-496088
American Medical Association (AMA)
Choi, Binhye& Chang, Mun Seog& Kim, Ha Young& Park, Jae-Woo& Ryu, Bongha& Kim, Jinsung. Effects of Low Level Laser Therapy on Ovalbumin-Induced Mouse Model of Allergic Rhinitis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-496088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496088