Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells
Joint Authors
Fullen, Khyra
Cook, Carla
Fei, Jia
Gillespie, Miriah
Yu, Bangning
Santanam, Nalini
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Atherogenic ω-6 lipids are physiological ligands of peroxisome proliferator-activated receptors (PPARs) and elicit pro- and antiatherogenic responses in vascular cells.
The objective of this study was to investigate if ω-6 lipids modulated the early growth response-1 (Egr-1)/PPAR crosstalk thereby altering vascular function.
Rat aortic smooth muscle cells (RASMCs) were exposed to ω-6 lipids, linoleic acid (LA), or its oxidized form, 13-HPODE (OxLA) in the presence or absence of a PPARα antagonist (MK886) or PPARγ antagonist (GW9662) or PPAR-specific siRNA.
Our results demonstrate that ω-6 lipids, induced Egr-1 and monocyte chemotactic protein-1 (MCP-1) mRNA and protein levels at the acute phase (1–4 hrs) when PPARα was downregulated and at subacute phase (4–12 hrs) by modulating PPARγ, thus resulting in altered monocyte adhesion to RASMCs.
We provide novel insights into the mechanism of action of ω-6 lipids on Egr-1/PPAR interactions in vascular cells and their potential in altering vascular function.
American Psychological Association (APA)
Fei, Jia& Cook, Carla& Gillespie, Miriah& Yu, Bangning& Fullen, Khyra& Santanam, Nalini. 2011. Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells. PPAR Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-496095
Modern Language Association (MLA)
Fei, Jia…[et al.]. Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells. PPAR Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-496095
American Medical Association (AMA)
Fei, Jia& Cook, Carla& Gillespie, Miriah& Yu, Bangning& Fullen, Khyra& Santanam, Nalini. Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells. PPAR Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-496095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496095