Bile Acid Signaling in Liver Metabolism and Diseases
Joint Authors
Li, Tiangang
Chiang, John Y. L.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Obesity, diabetes, and metabolic syndromes are increasingly recognized as health concerns worldwide.
Overnutrition and insulin resistance are the major causes of diabetic hyperglycemia and hyperlipidemia in humans.
Studies in the past decade provide evidence that bile acids are not just biological detergents facilitating gut nutrient absorption, but also important metabolic regulators of glucose and lipid homeostasis.
Pharmacological alteration of bile acid metabolism or bile acid signaling pathways such as using bile acid receptor agonists or bile acid binding resins may be a promising therapeutic strategy for the treatment of obesity and diabetes.
On the other hand, bile acid signaling is complex, and the molecular mechanisms mediating the bile acid effects are still not completely understood.
This paper will summarize recent advances in our understanding of bile acid signaling in regulation of glucose and lipid metabolism, and the potentials of developing novel therapeutic strategies that target bile acid metabolism for the treatment of metabolic disorders.
American Psychological Association (APA)
Li, Tiangang& Chiang, John Y. L.. 2011. Bile Acid Signaling in Liver Metabolism and Diseases. Journal of Lipids،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-496115
Modern Language Association (MLA)
Li, Tiangang& Chiang, John Y. L.. Bile Acid Signaling in Liver Metabolism and Diseases. Journal of Lipids No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-496115
American Medical Association (AMA)
Li, Tiangang& Chiang, John Y. L.. Bile Acid Signaling in Liver Metabolism and Diseases. Journal of Lipids. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-496115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496115