Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice
Joint Authors
Semenchenko, Anna V.
Wang, Zhao-Qi
Popovich, Irina G.
Piskunova, Tatiana S.
Zabezhinski, Mark A.
Yurova, Maria N.
Ovsyannikov, Anton I.
Anisimov, Vladimir N.
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging.
Here we show that PARP-1-/- mice exhibit a reduction of life span and a significant increase of population aging rate.
Analysis of noninvasive parameters, including body weight gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biological aging in PARP-1-/- mice.
The incidence of spontaneous tumors in both PARP-1-/- and PARP-1+/+ groups is similar; however, malignant tumors including uterine tumors, lung adenocarcinomas and hepatocellular carcinomas, develop at a significantly higher frequency in PARP-1-/- mice than PARP-1+/+ mice (72% and 49%, resp.; P< .05).
In addition, spontaneous tumors appear earlier in PARP-1-/- mice compared to the wild type group.
Histopathological studies revealed a wide spectrum of tumors in uterus, ovaries, liver, lungs, mammary gland, soft tissues, and lymphoid organs in both groups of the mice.
These results demonstrate that inactivation of DNA repair gene PARP-1 in mice leads to acceleration of aging, shortened life span, and increased spontaneous carcinogenesis.
American Psychological Association (APA)
Piskunova, Tatiana S.& Yurova, Maria N.& Ovsyannikov, Anton I.& Semenchenko, Anna V.& Zabezhinski, Mark A.& Popovich, Irina G.…[et al.]. 2008. Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice. Current Gerontology and Geriatrics Research،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-496131
Modern Language Association (MLA)
Piskunova, Tatiana S.…[et al.]. Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice. Current Gerontology and Geriatrics Research No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-496131
American Medical Association (AMA)
Piskunova, Tatiana S.& Yurova, Maria N.& Ovsyannikov, Anton I.& Semenchenko, Anna V.& Zabezhinski, Mark A.& Popovich, Irina G.…[et al.]. Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice. Current Gerontology and Geriatrics Research. 2008. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-496131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496131