In Vivo Evaluation of a Decellularized Limbal Graft for Limbal Reconstruction
Joint Authors
Milani, Behrad Y.
Djalilian, Ali R.
Shafiq, Maryam A.
Source
International Journal of Tissue Engineering
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Corneal and limbal epithelial function is highly dependent on its underlying matrix.
In this study, we report the in vitro and in vivo effects of a decellularized limbal matrix on corneal and limbal epithelial differentiation and repair.
We demonstrate that a limbal matrix helps to maintain epithelial cells in a more proliferative and less differentiated state.
We introduce a novel focal injury model to the limbus using an excimer laser and further show that transplanting a decellularized limbal graft after the limbal injury helps to promote epithelialization and reduce corneal haze formation.
These results suggest that a decellularized limbal graft may be therapeutically beneficial in clinical cases of focal limbal deficiency.
American Psychological Association (APA)
Shafiq, Maryam A.& Milani, Behrad Y.& Djalilian, Ali R.. 2014. In Vivo Evaluation of a Decellularized Limbal Graft for Limbal Reconstruction. International Journal of Tissue Engineering،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-496140
Modern Language Association (MLA)
Shafiq, Maryam A.…[et al.]. In Vivo Evaluation of a Decellularized Limbal Graft for Limbal Reconstruction. International Journal of Tissue Engineering No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-496140
American Medical Association (AMA)
Shafiq, Maryam A.& Milani, Behrad Y.& Djalilian, Ali R.. In Vivo Evaluation of a Decellularized Limbal Graft for Limbal Reconstruction. International Journal of Tissue Engineering. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-496140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496140