How to Recondition Ex Vivo Initially Rejected Donor Lungs for Clinical Transplantation : Clinical Experience from Lund University Hospital
Joint Authors
Eyjolfsson, Atli
Wierup, Per
Gustafsson, Ronny
Ingemansson, Richard
Pierre, Leif
Koul, Bansi
Lindstedt, Sandra
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A major problem in clinical lung transplantation is the shortage of donor lungs.
Only about 20% of donor lungs are accepted for transplantation.
We have recently reported the results of the first six double lung transplantations performed with donor lungs reconditioned ex vivo that had been deemed unsuitable for transplantation by the Scandiatransplant, Eurotransplant, and UK Transplant organizations because the arterial oxygen pressure was less than 40 kPa.
The three-month survival of patients undergoing transplant with these lungs was 100%.
One patient died due to sepsis after 95 days, and one due to rejection after 9 months.
Four recipients are still alive and well 24 months after transplantation, with no signs of bronchiolitis obliterans syndrome.
The donor lungs were reconditioned ex vivo in an extracorporeal membrane oxygenation circuit using STEEN solution mixed with erythrocytes, to dehydrate edematous lung tissue.
Functional evaluation was performed with deoxygenated perfusate at different inspired fractions of oxygen.
The arterial oxygen pressure was significantly improved in this model.
This ex vivo evaluation model is thus a valuable addition to the armamentarium in increasing the number of acceptable lungs in a donor population with inferior arterial oxygen pressure values, thereby, increasing the lung donor pool for transplantation.
In the following paper we present our clinical experience from the first six patients in the world.
We also present the technique we used in detail with flowchart.
American Psychological Association (APA)
Lindstedt, Sandra& Eyjolfsson, Atli& Koul, Bansi& Wierup, Per& Pierre, Leif& Gustafsson, Ronny…[et al.]. 2011. How to Recondition Ex Vivo Initially Rejected Donor Lungs for Clinical Transplantation : Clinical Experience from Lund University Hospital. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-496157
Modern Language Association (MLA)
Lindstedt, Sandra…[et al.]. How to Recondition Ex Vivo Initially Rejected Donor Lungs for Clinical Transplantation : Clinical Experience from Lund University Hospital. Journal of Transplantation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-496157
American Medical Association (AMA)
Lindstedt, Sandra& Eyjolfsson, Atli& Koul, Bansi& Wierup, Per& Pierre, Leif& Gustafsson, Ronny…[et al.]. How to Recondition Ex Vivo Initially Rejected Donor Lungs for Clinical Transplantation : Clinical Experience from Lund University Hospital. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-496157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496157