Acanthus ebracteatus Vahl. Ethanol Extract Enhancement of the Efficacy of the Collagen Scaffold in Wound Closure : A Study in a Full-Thickness-Wound Mouse Model
Joint Authors
Somchaichana, Jutamas
Patumraj, Suthiluk
Bunaprasert, Tanom
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acanthus ebracteatus Vahl.
is a Thai herb that is effective in wound healing.
We sought to quantitatively determine whether or not the combined application of Acanthus ebracteatus Vahl.
and a collagen scaffold will increase wound closure and angiogenesis.
Balb/c mice (body weight: 22–25 g) were anesthetized with sodium thiopental.
The dorsal skin incision measuring 1.5 × 1.5 cm was made and then deepened using scissors to produce a full-thickness incision down to the level of the panniculus carnosus.
The size of the wound was approximately 10% of the total body surface area.
The collagen sheet was implanted onto the wound.
Animals were divided into 4 major groups as follows: wound with normal saline (W-NSS), wound treated with 0.3 g/kg BW of Acanthus ebracteatus Vahl.
extract (W-AE (0.3 g/kg.bw)), wound implanted with collagen scaffold (W-Coll), and wound implanted with collagen scaffold and treated with 0.3 g/kg BW of Acanthus ebracteatus Vahl.
(W-Coll-AE combination).
On day 14, the W-Coll-AE group showed decreased wound areas and increased capillary vascularity (CV) when compared to the other 3 groups, W-NSS, W-AE0.3, and W-Coll.
In the present study, the combination of AE0.3 with collagen showed the best effect on skin angiogenesis and promoted wound closure with less neutrophil infiltration.
American Psychological Association (APA)
Somchaichana, Jutamas& Bunaprasert, Tanom& Patumraj, Suthiluk. 2012. Acanthus ebracteatus Vahl. Ethanol Extract Enhancement of the Efficacy of the Collagen Scaffold in Wound Closure : A Study in a Full-Thickness-Wound Mouse Model. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496162
Modern Language Association (MLA)
Somchaichana, Jutamas…[et al.]. Acanthus ebracteatus Vahl. Ethanol Extract Enhancement of the Efficacy of the Collagen Scaffold in Wound Closure : A Study in a Full-Thickness-Wound Mouse Model. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-496162
American Medical Association (AMA)
Somchaichana, Jutamas& Bunaprasert, Tanom& Patumraj, Suthiluk. Acanthus ebracteatus Vahl. Ethanol Extract Enhancement of the Efficacy of the Collagen Scaffold in Wound Closure : A Study in a Full-Thickness-Wound Mouse Model. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496162