Body Fat and Breast Cancer Risk in Postmenopausal Women : A Longitudinal Study
Joint Authors
Wassertheil-Smoller, Sylvia
Qi, Lihong
Rohan, Thomas E.
Freudenheim, Jo L.
Choi, Lydia
Datta, Mridul
Vitolins, Mara Z.
Kamensky, Victor
Heo, Moonseong
Kabat, Geoffrey C.
Ochs-Balcom, Heather M.
Thomson, Cynthia A.
Source
Journal of Cancer Epidemiology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Associations between anthropometric indices of obesity and breast cancer risk may fail to capture the true relationship between excess body fat and risk.
We used dual-energy-X-ray-absorptiometry- (DXA-) derived measures of body fat obtained in the Women’s Health Initiative to examine the association between body fat and breast cancer risk; we compared these risk estimates with those for conventional anthropometric measurements.
The study included 10,960 postmenopausal women aged 50–79 years at recruitment, with baseline DXA measurements and no history of breast cancer.
During followup (median: 12.9 years), 503 incident breast cancer cases were diagnosed.
Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models.
All baseline DXA-derived body fat measures showed strong positive associations with breast cancer risk.
The multivariable-adjusted HR for the uppermost quintile level (versus lowest) ranged from 1.53 (95% CI 1.14–2.07) for fat mass of the right leg to 2.05 (1.50–2.79) for fat mass of the trunk.
Anthropometric indices (categorized by quintiles) of obesity (BMI (1.97, 1.45–2.68), waist circumference (1.97, 1.46–2.65), and waist : hip ratio (1.91, 1.41–2.58)) were all strongly, positively associated with risk and did not differ from DXA-derived measures in prediction of risk.
American Psychological Association (APA)
Rohan, Thomas E.& Heo, Moonseong& Choi, Lydia& Datta, Mridul& Freudenheim, Jo L.& Kamensky, Victor…[et al.]. 2013. Body Fat and Breast Cancer Risk in Postmenopausal Women : A Longitudinal Study. Journal of Cancer Epidemiology،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-496189
Modern Language Association (MLA)
Rohan, Thomas E.…[et al.]. Body Fat and Breast Cancer Risk in Postmenopausal Women : A Longitudinal Study. Journal of Cancer Epidemiology No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-496189
American Medical Association (AMA)
Rohan, Thomas E.& Heo, Moonseong& Choi, Lydia& Datta, Mridul& Freudenheim, Jo L.& Kamensky, Victor…[et al.]. Body Fat and Breast Cancer Risk in Postmenopausal Women : A Longitudinal Study. Journal of Cancer Epidemiology. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-496189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496189