A Rare Case of Prototheca Algaemia in a Patient with Systemic Lupus Erythematosus and Recent Belimumab Infusion
Joint Authors
Singh, Shelley
Arias Urdaneta, Luis
Sesin, Carlos
Miller, Nanci Mae
Mejia-Otero, Carolina
Tuda, Claudio
Chakrabarti, Anindita
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-21
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Novel agents for the treatment of immune-mediated diseases such as systemic lupus erythematosus (SLE) have been increasingly used as an alternative to or in combination with conventional therapies.
Belimumab, a human monoclonal antibody that inhibits B-cell activating factor (BAFF), has demonstrated efficacy in moderate-to-severe SLE with similar adverse effects when compared to other biologic agents and conventional SLE therapies.
Here, we describe a woman with SLE and diabetes mellitus (DM) on immunosuppressive therapy for five years who was admitted to the hospital for pneumonia but had a complicated hospital course with multiple infections and, most notably, a nosocomial algaemia due to Prototheca wickerhamii, which was treated successfully with amphotericin B.
She had recently received three belimumab infusions as an outpatient prior to admission to the hospital.
To the best of our knowledge no cases of human protothecosis in patients receiving belimumab have been described in the English literature; however, unusual infections have to be considered in all patients undergoing immunosuppressive therapies who persist with fever despite conventional antimicrobials.
American Psychological Association (APA)
Mejia-Otero, Carolina& Singh, Shelley& Arias Urdaneta, Luis& Sesin, Carlos& Chakrabarti, Anindita& Miller, Nanci Mae…[et al.]. 2012. A Rare Case of Prototheca Algaemia in a Patient with Systemic Lupus Erythematosus and Recent Belimumab Infusion. Case Reports in Immunology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-496196
Modern Language Association (MLA)
Mejia-Otero, Carolina…[et al.]. A Rare Case of Prototheca Algaemia in a Patient with Systemic Lupus Erythematosus and Recent Belimumab Infusion. Case Reports in Immunology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-496196
American Medical Association (AMA)
Mejia-Otero, Carolina& Singh, Shelley& Arias Urdaneta, Luis& Sesin, Carlos& Chakrabarti, Anindita& Miller, Nanci Mae…[et al.]. A Rare Case of Prototheca Algaemia in a Patient with Systemic Lupus Erythematosus and Recent Belimumab Infusion. Case Reports in Immunology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-496196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496196