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Association of Epidermal Growth Factor Receptor Mutations with Metastatic Presentations in Non-Small Cell Lung Cancer
Joint Authors
Park, Jong Heon
Na, Im Il
Lee, Jin Kyung
Koh, Jae Soo
Choe, Du Hwan
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We performed this retrospective study to assess the association of epidermal growth factor receptor (EGFR) with metastatic presentations in advanced non-small cell lung cancer (NSCLC).
The data from 125 patients with stage III or IV NSCLC were analyzed.
We detected EGFR mutations in 36 NSCLC patients.
EGFR mutations were predominant in never-smokers (P<.001), patients with adenocarcinomas (P<.001), and female patients (P<.001).
When the metastatic sites were analyzed, pleural metastases were associated with a high incidence of EGFR mutations (P=.028).
Particularly, pleural metastases with minimal effusion (PMME) were associated with EGFR mutational status (P=.001).
Patients with N3 lesions were less likely to harbor EGFR mutations (P=.033).
On multivariate analysis, N3 lesions (P=.017) and PMME (P<.001) remained significant factors for EGFR mutations.
EGFR mutations may be associated with different presentations of pleural and N3 nodal metastases.
American Psychological Association (APA)
Na, Im Il& Park, Jong Heon& Choe, Du Hwan& Lee, Jin Kyung& Koh, Jae Soo. 2011. Association of Epidermal Growth Factor Receptor Mutations with Metastatic Presentations in Non-Small Cell Lung Cancer. ISRN Oncology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-496237
Modern Language Association (MLA)
Na, Im Il…[et al.]. Association of Epidermal Growth Factor Receptor Mutations with Metastatic Presentations in Non-Small Cell Lung Cancer. ISRN Oncology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-496237
American Medical Association (AMA)
Na, Im Il& Park, Jong Heon& Choe, Du Hwan& Lee, Jin Kyung& Koh, Jae Soo. Association of Epidermal Growth Factor Receptor Mutations with Metastatic Presentations in Non-Small Cell Lung Cancer. ISRN Oncology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-496237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496237