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Microparticles : A New Perspective in Central Nervous System Disorders
Joint Authors
Klegeris, Andis
Schindler, Stephanie M.
Little, Jonathan P.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Microparticles (MPs) are a heterogeneous population of small cell-derived vesicles, ranging in size from 0.1 to 1 μm.
They contain a variety of bioactive molecules, including proteins, biolipids, and nucleic acids, which can be transferred between cells without direct cell-to-cell contact.
Consequently, MPs represent a novel form of intercellular communication, which could play a role in both physiological and pathological processes.
Growing evidence indicates that circulating MPs contribute to the development of cancer, inflammation, and autoimmune and cardiovascular diseases.
Most cell types of the central nervous system (CNS) have also been shown to release MPs, which could be important for neurodevelopment, CNS maintenance, and pathologies.
In disease, levels of certain MPs appear elevated; therefore, they may serve as biomarkers allowing for the development of new diagnostic tools for detecting the early stages of CNS pathologies.
Quantification and characterization of MPs could also provide useful information for making decisions on treatment options and for monitoring success of therapies, particularly for such difficult-to-treat diseases as cerebral malaria, multiple sclerosis, and Alzheimer’s disease.
Overall, studies on MPs in the CNS represent a novel area of research, which promises to expand the knowledge on the mechanisms governing some of the physiological and pathophysiological processes of the CNS.
American Psychological Association (APA)
Schindler, Stephanie M.& Little, Jonathan P.& Klegeris, Andis. 2014. Microparticles : A New Perspective in Central Nervous System Disorders. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-496247
Modern Language Association (MLA)
Schindler, Stephanie M.…[et al.]. Microparticles : A New Perspective in Central Nervous System Disorders. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-496247
American Medical Association (AMA)
Schindler, Stephanie M.& Little, Jonathan P.& Klegeris, Andis. Microparticles : A New Perspective in Central Nervous System Disorders. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-496247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496247