Towards Therapeutic Applications of Arthropod Venom K+-Channel Blockers in CNS Neurologic Diseases Involving Memory Acquisition and Storage
Joint Authors
Schwartz, Elisabeth F.
Gati, Christiano D. C.
Mortari, Márcia R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Potassium channels are the most heterogeneous and widely distributed group of ion channels and play important functions in all cells, in both normal and pathological mechanisms, including learning and memory processes.
Being fundamental for many diverse physiological processes, K+-channels are recognized as potential therapeutic targets in the treatment of several Central Nervous System (CNS) diseases, such as multiple sclerosis, Parkinson's and Alzheimer's diseases, schizophrenia, HIV-1-associated dementia, and epilepsy.
Blockers of these channels are therefore potential candidates for the symptomatic treatment of these neuropathies, through their neurological effects.
Venomous animals have evolved a wide set of toxins for prey capture and defense.
These compounds, mainly peptides, act on various pharmacological targets, making them an innumerable source of ligands for answering experimental paradigms, as well as for therapeutic application.
This paper provides an overview of CNS K+-channels involved in memory acquisition and storage and aims at evaluating the use of highly selective K+-channel blockers derived from arthropod venoms as potential therapeutic agents for CNS diseases involving learning and memory mechanisms.
American Psychological Association (APA)
Gati, Christiano D. C.& Mortari, Márcia R.& Schwartz, Elisabeth F.. 2012. Towards Therapeutic Applications of Arthropod Venom K+-Channel Blockers in CNS Neurologic Diseases Involving Memory Acquisition and Storage. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-496251
Modern Language Association (MLA)
Gati, Christiano D. C.…[et al.]. Towards Therapeutic Applications of Arthropod Venom K+-Channel Blockers in CNS Neurologic Diseases Involving Memory Acquisition and Storage. Journal of Toxicology No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-496251
American Medical Association (AMA)
Gati, Christiano D. C.& Mortari, Márcia R.& Schwartz, Elisabeth F.. Towards Therapeutic Applications of Arthropod Venom K+-Channel Blockers in CNS Neurologic Diseases Involving Memory Acquisition and Storage. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-496251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496251