Metastatic Squamous Cell Carcinoma of the Anus : Time for a Shift in the Treatment Paradigm?
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Anal cancers are rare tumours; however, the incidence is increasing in both men and women.
Changing trends in sexual behaviour, smoking, and infection with the human papillomavirus are thought to be responsible for the increase.
Patients with metastatic disease have a poor prognosis, with 5-year median overall survival rates of 10% in men and 20% in women.
The standard systemic treatment of metastatic disease remains cisplatin and 5-fluorouracil, and aside from several non-randomised small phase II trials there has been no real progress over the past two decades.
Based on the efficacy of cetuximab in squamous cell carcinomas from other primary sites, there appears to be clinical rationale for evaluation of anti-epidermal growth factor inhibitors in anal squamous cell carcinoma.
In order to facilitate research and implement more effective treatment strategies international collaboration in clinical trials incorporating tissue collection for biomarkers is essential.
American Psychological Association (APA)
Dewdney, Alice& Rao, Sheela. 2012. Metastatic Squamous Cell Carcinoma of the Anus : Time for a Shift in the Treatment Paradigm?. ISRN Oncology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-496273
Modern Language Association (MLA)
Dewdney, Alice& Rao, Sheela. Metastatic Squamous Cell Carcinoma of the Anus : Time for a Shift in the Treatment Paradigm?. ISRN Oncology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-496273
American Medical Association (AMA)
Dewdney, Alice& Rao, Sheela. Metastatic Squamous Cell Carcinoma of the Anus : Time for a Shift in the Treatment Paradigm?. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-496273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496273