Mitochondrial Mechanisms of Neuroglobin’s Neuroprotection
Joint Authors
Yu, Zhanyang
Wang, Xiaoying
Poppe, Jessica L.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Neuroglobin (Ngb) is an oxygen-binding globin protein that has been demonstrated to be neuroprotective against stroke and related neurological disorders.
However, the underlying mechanisms of Ngb’s neuroprotection remain largely undefined.
Mitochondria play critical roles in multiple physiological pathways including cell respiration, energy production, free radical generation, and cellular homeostasis and apoptosis.
Mitochondrial dysfunction is widely involved in the pathogenesis of stroke and neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
Accumulating evidence showed that elevated Ngb level is associated with preserved mitochondrial function, suggesting that Ngb may play neuroprotective roles through mitochondria-mediated pathways.
In this paper we briefly discuss the mitochondria-related mechanisms in Ngb’s neuroprotection, especially those involved in ATP production, ROS generation and scavenging, and mitochondria-mediated cell death signaling pathways.
American Psychological Association (APA)
Yu, Zhanyang& Poppe, Jessica L.& Wang, Xiaoying. 2013. Mitochondrial Mechanisms of Neuroglobin’s Neuroprotection. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-496300
Modern Language Association (MLA)
Yu, Zhanyang…[et al.]. Mitochondrial Mechanisms of Neuroglobin’s Neuroprotection. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-496300
American Medical Association (AMA)
Yu, Zhanyang& Poppe, Jessica L.& Wang, Xiaoying. Mitochondrial Mechanisms of Neuroglobin’s Neuroprotection. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-496300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496300