Gene Therapy for Parkinson's Disease
Joint Authors
Denyer, Rachel
Douglas, Michael R.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Current pharmacological and surgical treatments for Parkinson's disease offer symptomatic improvements to those suffering from this incurable degenerative neurological disorder, but none of these has convincingly shown effects on disease progression.
Novel approaches based on gene therapy have several potential advantages over conventional treatment modalities.
These could be used to provide more consistent dopamine supplementation, potentially providing superior symptomatic relief with fewer side effects.
More radically, gene therapy could be used to correct the imbalances in basal ganglia circuitry associated with the symptoms of Parkinson's disease, or to preserve or restore dopaminergic neurons lost during the disease process itself.
The latter neuroprotective approach is the most exciting, as it could theoretically be disease modifying rather than simply symptom alleviating.
Gene therapy agents using these approaches are currently making the transition from the laboratory to the bedside.
This paper summarises the theoretical approaches to gene therapy for Parkinson's disease and the findings of clinical trials in this rapidly changing field.
American Psychological Association (APA)
Denyer, Rachel& Douglas, Michael R.. 2012. Gene Therapy for Parkinson's Disease. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-496332
Modern Language Association (MLA)
Denyer, Rachel& Douglas, Michael R.. Gene Therapy for Parkinson's Disease. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-496332
American Medical Association (AMA)
Denyer, Rachel& Douglas, Michael R.. Gene Therapy for Parkinson's Disease. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-496332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496332