5-Androstenediol Ameliorates Pleurisy, Septic Shock, and Experimental Autoimmune Encephalomyelitis in Mice
Joint Authors
Frincke, James M.
Reading, Christopher L.
Auci, Dominick L.
Flores-Riveros, Jaime
Nicoletti, Ferdinando
Mangano, Katia
Villegas, Sonia
Offner, Halina
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Androstenediol (androst-5-ene-3β,17β-diol; 5-AED), a natural adrenal steroid, has been shown to suppress experimental autoimmune encephalomyelitis (EAE) in female SJL/J mice.
We here report that 5-AED limits inflammation and proinflammatory cytokines including TNFα in murine models of carrageenan-induced pleurisy and lippopolysaccaride- (LPS) induced septic shock.
5-AED binds to and transactivates sex steroid receptors with the same general rank order of potency (ERβ > ERα ≫ AR).
5-AED provides benefit in EAE in a dose-dependent fashion, even when treatment is delayed until onset of disease.
The minimally effective dose may be as low as 4 mg/kg in mice.
However, benefit was not observed when 5-AED was given in soluble formulation, leading to a short half-life and rapid clearance.
These observations suggest that treatment with 5-AED limits the production of pro-inflammatory cytokines in these animal models and, ultimately, when formulated and administered properly, may be beneficial for patients with multiple sclerosis and other Th1-driven autoimmune diseases.
American Psychological Association (APA)
Nicoletti, Ferdinando& Auci, Dominick L.& Mangano, Katia& Flores-Riveros, Jaime& Villegas, Sonia& Frincke, James M.…[et al.]. 2010. 5-Androstenediol Ameliorates Pleurisy, Septic Shock, and Experimental Autoimmune Encephalomyelitis in Mice. Autoimmune Diseases،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-496345
Modern Language Association (MLA)
Nicoletti, Ferdinando…[et al.]. 5-Androstenediol Ameliorates Pleurisy, Septic Shock, and Experimental Autoimmune Encephalomyelitis in Mice. Autoimmune Diseases No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-496345
American Medical Association (AMA)
Nicoletti, Ferdinando& Auci, Dominick L.& Mangano, Katia& Flores-Riveros, Jaime& Villegas, Sonia& Frincke, James M.…[et al.]. 5-Androstenediol Ameliorates Pleurisy, Septic Shock, and Experimental Autoimmune Encephalomyelitis in Mice. Autoimmune Diseases. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-496345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496345