PPARs in Liver Diseases and Cancer : Epigenetic Regulation by MicroRNAs
Joint Authors
Foti, Michelangelo
Peyrou, Marion
Bourgoin, Lucie
Ramadori, Pierluigi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome-proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that exert in the liver a transcriptional activity regulating a whole spectrum of physiological functions, including cholesterol and bile acid homeostasis, lipid/glucose metabolism, inflammatory responses, regenerative mechanisms, and cell differentiation/proliferation.
Dysregulations of the expression, or activity, of specific PPAR isoforms in the liver are therefore believed to represent critical mechanisms contributing to the development of hepatic metabolic diseases, disorders induced by hepatic viral infections, and hepatocellular adenoma and carcinoma.
In this regard, specific PPAR agonists have proven to be useful to treat these metabolic diseases, but for cancer therapies, the use of PPAR agonists is still debated.
Interestingly, in addition to previously described mechanisms regulating PPARs expression and activity, microRNAs are emerging as new important regulators of PPAR expression and activity in pathophysiological conditions and therefore may represent future therapeutic targets to treat hepatic metabolic disorders and cancers.
Here, we reviewed the current knowledge about the general roles of the different PPAR isoforms in common chronic metabolic and infectious liver diseases, as well as in the development of hepatic cancers.
Recent works highlighting the regulation of PPARs by microRNAs in both physiological and pathological situations with a focus on the liver are also discussed.
American Psychological Association (APA)
Peyrou, Marion& Ramadori, Pierluigi& Bourgoin, Lucie& Foti, Michelangelo. 2012. PPARs in Liver Diseases and Cancer : Epigenetic Regulation by MicroRNAs. PPAR Research،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-496369
Modern Language Association (MLA)
Peyrou, Marion…[et al.]. PPARs in Liver Diseases and Cancer : Epigenetic Regulation by MicroRNAs. PPAR Research No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-496369
American Medical Association (AMA)
Peyrou, Marion& Ramadori, Pierluigi& Bourgoin, Lucie& Foti, Michelangelo. PPARs in Liver Diseases and Cancer : Epigenetic Regulation by MicroRNAs. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-496369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496369