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Reorganization of Extracellular Matrix in Placentas from Women with Asymptomatic Chagas Disease : Mechanism of Parasite Invasion or Local Placental Defense?
Joint Authors
Maya, Juan Diego
Corral, Gabriela
Zulantay, Inés
Cabrera, Gonzalo
Apt, Werner
Castillo, Christian
Yanez, Erika
Galanti, Norbel
Duaso, Juan
Kemmerling, Ulrike
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chagas disease, produced by the protozoan Trypanosoma cruzi (T.
cruzi), is one of the most frequent endemic diseases in Latin America.
In spite the fact that in the past few years T.
cruzi congenital transmission has become of epidemiological importance, studies about this mechanism of infection are scarce.
In order to explore some morphological aspects of this infection in the placenta, we analyzed placentas from T.
cruzi-infected mothers by immunohistochemical and histochemical methods.
Infection in mothers, newborns, and placentas was confirmed by PCR and by immunofluorescence in the placenta.
T.
cruzi-infected placentas present destruction of the syncytiotrophoblast and villous stroma, selective disorganization of the basal lamina, and disorganization of collagen I in villous stroma.
Our results suggest that the parasite induces reorganization of this tissue component and in this way may regulate both inflammatory and immune responses in the host.
Changes in the ECM of placental tissues, together with the immunological status of mother and fetus, and parasite load may determine the probability of congenital transmission of T.
cruzi.
American Psychological Association (APA)
Duaso, Juan& Yanez, Erika& Castillo, Christian& Galanti, Norbel& Cabrera, Gonzalo& Corral, Gabriela…[et al.]. 2011. Reorganization of Extracellular Matrix in Placentas from Women with Asymptomatic Chagas Disease : Mechanism of Parasite Invasion or Local Placental Defense?. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496423
Modern Language Association (MLA)
Duaso, Juan…[et al.]. Reorganization of Extracellular Matrix in Placentas from Women with Asymptomatic Chagas Disease : Mechanism of Parasite Invasion or Local Placental Defense?. Journal of Tropical Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-496423
American Medical Association (AMA)
Duaso, Juan& Yanez, Erika& Castillo, Christian& Galanti, Norbel& Cabrera, Gonzalo& Corral, Gabriela…[et al.]. Reorganization of Extracellular Matrix in Placentas from Women with Asymptomatic Chagas Disease : Mechanism of Parasite Invasion or Local Placental Defense?. Journal of Tropical Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496423