Effects of the Use of Non-Calcium Phosphate Binders in the Control and Outcome of Vascular Calcifications : A Review of Clinical Trials on CKD Patients
Author
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Vascular calcifications produce a high impact on morbidity and mortality rates in patients affected by chronic kidney disease and mineral bone disorder (CKD-MBD).
Effects are manifested from the more advanced stages of CKD (stages 3-4), particularly in patients undergoing dialysis (CKD5D).
In recent years, a large number of therapeutic options have been successfully used in the treatment of secondary hyperparathyroidism (SHPT), despite eliciting less marked effects on nonbone calcifications associated with CKD-MBD.
In addition to the use of Vitamin D and analogues, more recently treatment with calcimimetic drugs has also been undertaken.
The present paper aims to analyze comparative and efficacy studies undertaken to assess particularly the impact on morbidity and mortality rates of non-calcium phosphate binders.
Moreover, the mechanism of action underlying the depositing of calcium and phosphate along blood vessel walls, irrespective of the specific contribution provided in reducing the typical phosphate levels observed in CKD largely at more advanced stages of the disease, will be investigated.
The aim of this paper therefore is to evaluate which phosphate binders are characterised by the above action and the mechanisms through which these are manifested.
American Psychological Association (APA)
Bolasco, Piergiorgio. 2011. Effects of the Use of Non-Calcium Phosphate Binders in the Control and Outcome of Vascular Calcifications : A Review of Clinical Trials on CKD Patients. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-496432
Modern Language Association (MLA)
Bolasco, Piergiorgio. Effects of the Use of Non-Calcium Phosphate Binders in the Control and Outcome of Vascular Calcifications : A Review of Clinical Trials on CKD Patients. International Journal of Nephrology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-496432
American Medical Association (AMA)
Bolasco, Piergiorgio. Effects of the Use of Non-Calcium Phosphate Binders in the Control and Outcome of Vascular Calcifications : A Review of Clinical Trials on CKD Patients. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-496432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496432