The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells : Stromal Derived Factor 1 Is Not the Only Player in the Game
Joint Authors
Ratajczak, Janina
Janowska-Wieczorek, Anna
Ratajczak, Mariusz Z.
Kim, ChiHwa
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The α-chemokine stromal derived factor 1 (SDF-1), which binds to the CXCR4 and CXCR7 receptors, directs migration and homing of CXCR4+ hematopoietic stem/progenitor cells (HSPCs) to bone marrow (BM) and plays a crucial role in retention of these cells in stem cell niches.
However, this unique role of SDF-1 has been recently challenged by several observations supporting SDF-1-CXCR4-independent BM homing.
Specifically, it has been demonstrated that HSPCs respond robustly to some bioactive lipids, such as sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P), and migrate in response to gradients of certain extracellular nucleotides, including uridine triphosphate (UTP) and adenosine triphosphate (ATP).
Moreover, the responsiveness of HSPCs to an SDF-1 gradient is enhanced by some elements of innate immunity (e.g., C3 complement cascade cleavage fragments and antimicrobial cationic peptides, such as cathelicidin/LL-37 or β2-defensin) as well as prostaglandin E2 (PGE2).
Since all these factors are upregulated in BM after myeloblative conditioning for transplantation, a more complex picture of homing emerges that involves several factors supporting, and in some situations even replacing, the SDF-1-CXCR4 axis.
American Psychological Association (APA)
Ratajczak, Mariusz Z.& Kim, ChiHwa& Janowska-Wieczorek, Anna& Ratajczak, Janina. 2012. The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells : Stromal Derived Factor 1 Is Not the Only Player in the Game. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-496434
Modern Language Association (MLA)
Ratajczak, Mariusz Z.…[et al.]. The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells : Stromal Derived Factor 1 Is Not the Only Player in the Game. The Scientific World Journal No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-496434
American Medical Association (AMA)
Ratajczak, Mariusz Z.& Kim, ChiHwa& Janowska-Wieczorek, Anna& Ratajczak, Janina. The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells : Stromal Derived Factor 1 Is Not the Only Player in the Game. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-496434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496434