Pivotal Roles of MonocytesMacrophages in Stroke
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Stroke is an important issue in public health due to its high rates both of morbidity and mortality, and high rate of disability.
Hypertension, cardiovascular disease, arterial fibrillation, diabetes mellitus, smoking, and alcohol abuse are all risk factors for stroke.
Clinical observations suggest that inflammation is also a direct risk factor for stroke.
Patients with stroke have high levels of inflammatory cytokines in plasma, and immune cells, such as macrophages and T-lymphocytes, are noted within stroke lesions.
These inflammatory events are considered as a result of stroke.
However, recent studies show that plasma levels of inflammatory cytokines or soluble adhesion molecules are high in patients without stroke, and anti-inflammatory therapy is effective at reducing stroke incidence in not only animal models, but in humans as well.
Statins have been shown to decrease the stroke incidence via anti-inflammatory effects that are both dependent and independent of their cholesterol-lowering effects.
These reports suggest that inflammation might directly affect the onset of stroke.
Microglial cells and blood-derived monocytes/macrophages play important roles in inflammation in both onset and aggravation of stroke lesions.
We review the recent findings regarding the role of monocytes/macrophages in stroke.
American Psychological Association (APA)
Chiba, Tsuyoshi& Umegaki, Keizo. 2013. Pivotal Roles of MonocytesMacrophages in Stroke. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496486
Modern Language Association (MLA)
Chiba, Tsuyoshi& Umegaki, Keizo. Pivotal Roles of MonocytesMacrophages in Stroke. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-496486
American Medical Association (AMA)
Chiba, Tsuyoshi& Umegaki, Keizo. Pivotal Roles of MonocytesMacrophages in Stroke. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496486