Xiaoqinglong Granules as Add-On Therapy for Asthma : Latent Class Analysis of Symptom Predictors of Response
Joint Authors
Xue, Hanrong
Chang, Christopher
Xiao, Zuke
Chen, Jianjian
Lu, Cheng
Shang, Yunfei
Liu, Yan
Zha, Qinglin
Lu, Ai-ping
Wen, Minyong
Jiang, Miao
Lin, Seqi
Zhang, Chi
Liu, Weiyou
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Xiaoqinglong granules (XQLG) has been shown to be an effective therapy in asthma animal models.
We reviewed the literature and conducted this study to assess the impact of XQLG as an add-on therapy to treatment with fluticasone/salmeterol (seretide) in adult patients with mild-to-moderate, persistent asthma.
A total of 178 patients were randomly assigned to receive XQLG and seretide or seretide plus placebo for 90 days.
Asthma control was assessed by asthma control test (ACT), symptoms scores, FEV1, and PEF.
Baseline patient-reported Chinese medicine (CM)-specific symptoms were analyzed to determine whether the symptoms may be possible indicators of treatment response by conducting latent class analysis (LCA).
There was no statistically significant difference in ACT score between two groups.
In the subset of 70 patients with symptoms defined by CM criteria, XQLG add-on therapy was found to significantly increase the levels of asthma control according to global initiative for asthma (GINA) guidelines (P=0.0329).
There was no significant difference in another subset of 100 patients with relatively low levels of the above-mentioned symptoms (P=0.1291).
Results of LCA suggest that patients with the six typical symptoms defined in CM may benefit from XQLG.
American Psychological Association (APA)
Zha, Qinglin& Lin, Seqi& Zhang, Chi& Chang, Christopher& Xue, Hanrong& Lu, Cheng…[et al.]. 2013. Xiaoqinglong Granules as Add-On Therapy for Asthma : Latent Class Analysis of Symptom Predictors of Response. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496525
Modern Language Association (MLA)
Zha, Qinglin…[et al.]. Xiaoqinglong Granules as Add-On Therapy for Asthma : Latent Class Analysis of Symptom Predictors of Response. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-496525
American Medical Association (AMA)
Zha, Qinglin& Lin, Seqi& Zhang, Chi& Chang, Christopher& Xue, Hanrong& Lu, Cheng…[et al.]. Xiaoqinglong Granules as Add-On Therapy for Asthma : Latent Class Analysis of Symptom Predictors of Response. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496525