A Comparative Analysis of Mast Cell Quantification in Five Common Dermatoses : Lichen Simplex Chronicus, Psoriasis, Lichen Planus, Lupus, and Insect BiteAllergic Contact DermatitisNummular Dermatitis
Joint Authors
Mohammadi, Amir
Rhatigan, Ronald
Patel, Nikhil
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
There is a large body of literature demonstrating an important role of mast cells in adaptive and innate immunity.
The distribution of mast cells in the skin varies in different parts of the body.
It is well known that mast cells are important for effector functions of classic IgE-associated allergic disorders as well as in host defense against infective agents and influence the manifestation of autoimmune diseases.
We aimed to quantify mast cells in five common dermatoses and compare them statistically with respect to the immunostains.
We retrieved paraffin-embedded tissue sections from the archives of the Pathology Department at the UF, Jacksonville, for five cases with each of the above diagnosis from the last three years.
We performed CD-117 and tolidine blue stains on each one of them.
The presence or absence of mast cells was evaluated and quantified.
We observed that, in the skin, mast cells are mainly located close to the vessels, smooth muscle cells, hair follicles, and nerve ending.
Our study showed that the mast cell distribution pattern is different across the two methods of staining for the five aforesaid dermatoses.
The other important observation was the dendritic morphology of the mast cells.
American Psychological Association (APA)
Patel, Nikhil& Mohammadi, Amir& Rhatigan, Ronald. 2012. A Comparative Analysis of Mast Cell Quantification in Five Common Dermatoses : Lichen Simplex Chronicus, Psoriasis, Lichen Planus, Lupus, and Insect BiteAllergic Contact DermatitisNummular Dermatitis. ISRN Dermatology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496540
Modern Language Association (MLA)
Patel, Nikhil…[et al.]. A Comparative Analysis of Mast Cell Quantification in Five Common Dermatoses : Lichen Simplex Chronicus, Psoriasis, Lichen Planus, Lupus, and Insect BiteAllergic Contact DermatitisNummular Dermatitis. ISRN Dermatology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-496540
American Medical Association (AMA)
Patel, Nikhil& Mohammadi, Amir& Rhatigan, Ronald. A Comparative Analysis of Mast Cell Quantification in Five Common Dermatoses : Lichen Simplex Chronicus, Psoriasis, Lichen Planus, Lupus, and Insect BiteAllergic Contact DermatitisNummular Dermatitis. ISRN Dermatology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496540