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Loss of the Desmosomal Component Perp Impairs Wound Healing In Vivo
Joint Authors
Ihrie, Rebecca A.
Park, Eunice
Jacobs, Suzanne B. R.
Beaudry, Veronica G.
Pathak, Navneeta
Nguyen, Bichchau
Attardi, Laura D.
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Epithelial wound closure is a complex biological process that relies on the concerted action of activated keratinocytes and dermal fibroblasts to resurface and close the exposed wound.
Modulation of cell-cell adhesion junctions is thought to facilitate cellular proliferation and migration of keratinocytes across the wound.
In particular, desmosomes, adhesion complexes critical for maintaining epithelial integrity, are downregulated at the wound edge.
It is unclear, however, how compromised desmosomal adhesion would affect wound reepithelialization, given the need for a delicate balance between downmodulating adhesive strength to permit changes in cellular morphology and maintaining adhesion to allow coordinated migration of keratinocyte sheets.
Here, we explore the contribution of desmosomal adhesion to wound healing using mice deficient for the desmosomal component Perp.
We find that Perp conditional knockout mice display delayed wound healing relative to controls.
Furthermore, we determine that while loss of Perp compromises cell-cell adhesion, it does not impair keratinocyte proliferation and actually enhances keratinocyte migration in in vitro assays.
Thus, Perp's role in promoting cell adhesion is essential for wound closure.
Together, these studies suggest a role for desmosomal adhesion in efficient wound healing.
American Psychological Association (APA)
Beaudry, Veronica G.& Ihrie, Rebecca A.& Jacobs, Suzanne B. R.& Nguyen, Bichchau& Pathak, Navneeta& Park, Eunice…[et al.]. 2010. Loss of the Desmosomal Component Perp Impairs Wound Healing In Vivo. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-496546
Modern Language Association (MLA)
Beaudry, Veronica G.…[et al.]. Loss of the Desmosomal Component Perp Impairs Wound Healing In Vivo. Dermatology Research and Practice No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-496546
American Medical Association (AMA)
Beaudry, Veronica G.& Ihrie, Rebecca A.& Jacobs, Suzanne B. R.& Nguyen, Bichchau& Pathak, Navneeta& Park, Eunice…[et al.]. Loss of the Desmosomal Component Perp Impairs Wound Healing In Vivo. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-496546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496546