Development of Murine Hepatic NK Cells during Ontogeny : Comparison with Spleen NK Cells
Joint Authors
Tian, Zhigang
Wei, Haiming
Sun, Rui
Wu, Xian
Chen, Yongyan
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The phenotype of developing liver NK cells (CD3−NK1.1+) was investigated during mouse ontogeny comparing with spleen NK cells.
The highest percentage of hepatic CD27−CD11b− NK cells occurred at the fetal stage.
After birth, the percentage of CD27−CD11b−NK cells in both the liver and spleen gradually decreased to their lowest level at 6 weeks.
More CD27+CD11b−NK cells were detected in the liver than that in spleen from week 1 to 6.
Expression of NKG2A on liver NK cells was decreased but still much higher than that of spleen NK cells after 1 week.
The NKG2D expression on liver NK cells increased to its highest level and was significantly higher than on spleen NK cells till 4 weeks.
During mouse ontogeny, weaker expression of NKp46 and CD2 and stronger expression of CD69, CD11c, 2B4, and CD73 were observed on liver NK cells.
Furthermore, neonatal liver NK cells express higher IFN-γ and perforin than adult .These results suggest that the maturation process of NK cells is unique in the livers, and liver microenvironments might play critical roles to keep NK cells in an immature status.
American Psychological Association (APA)
Wu, Xian& Chen, Yongyan& Wei, Haiming& Sun, Rui& Tian, Zhigang. 2011. Development of Murine Hepatic NK Cells during Ontogeny : Comparison with Spleen NK Cells. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-496552
Modern Language Association (MLA)
Wu, Xian…[et al.]. Development of Murine Hepatic NK Cells during Ontogeny : Comparison with Spleen NK Cells. Clinical and Developmental Immunology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-496552
American Medical Association (AMA)
Wu, Xian& Chen, Yongyan& Wei, Haiming& Sun, Rui& Tian, Zhigang. Development of Murine Hepatic NK Cells during Ontogeny : Comparison with Spleen NK Cells. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-496552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496552