Feminizing Adrenal Carcinoma Presenting with Heart Failure and Ventricular Tachycardia
Joint Authors
West, R. Lee
Harnoor, Anjana
Cook, Fiona J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We present a case of feminizing adrenal carcinoma with severe elevation in serum estradiol and otherwise unexplained congestive heart failure with ventricular arrhythmia and review the literature on feminizing adrenal tumors and the potential relationship between estrogen and cardiac problems.
A 54-year-old man presented with congestive heart failure and ventricular arrhythmia.
Imaging revealed a large adrenal mass.
Hormonal evaluation revealed a very high serum level of estradiol, elevated DHEA-sulfate and androstenedione, and lack of cortisol suppression on a low-dose overnight dexamethasone suppression test.
The patient underwent a left adrenalectomy with subsequent normalization of serum estradiol.
Surgical pathology examination established adrenocortical carcinoma MacFarlane stage II.
Upon 15-month followup, the patient continued to have a normal serum estradiol level, his cardiac function was significantly improved, and he had no further episodes of ventricular arrhythmia.
To the best of our knowledge, the serum estradiol level that was detected in our case is the highest that has been reported.
Further, we hypothesize that the very high serum concentration of estradiol in our case may have played a role in his cardiac presentation with congestive heart failure and arrhythmia, particularly as these problems resolved with normalization of his serum estradiol level.
American Psychological Association (APA)
Harnoor, Anjana& West, R. Lee& Cook, Fiona J.. 2012. Feminizing Adrenal Carcinoma Presenting with Heart Failure and Ventricular Tachycardia. Case Reports in Endocrinology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496573
Modern Language Association (MLA)
Harnoor, Anjana…[et al.]. Feminizing Adrenal Carcinoma Presenting with Heart Failure and Ventricular Tachycardia. Case Reports in Endocrinology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-496573
American Medical Association (AMA)
Harnoor, Anjana& West, R. Lee& Cook, Fiona J.. Feminizing Adrenal Carcinoma Presenting with Heart Failure and Ventricular Tachycardia. Case Reports in Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496573