Cortical Pathology in RRMS : Taking a Cue from Four Sisters

Joint Authors

Calabrese, Massimiliano
Gallo, Paolo
Rinaldi, Francesca
Cocco, Eleonora
Seppi, Dario
Poretto, Valentina
Perini, Paola

Source

Multiple Sclerosis International

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-09-27

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine

Abstract EN

Background.

Although grey matter pathology is a relevant aspect of multiple sclerosis (MS) both with physical and cognitive rebounds, its pathogenesis is still under investigation.

To what extent the familial and sporadic cases of MS differ in cortical pathology has not been elucidated yet.

Here we present a multiple case report of four sisters affected by MS, all of them having a very high burden of cortical pathology.

Methods.

The clinical and grey matter MRI parameters of the patients were compared with those of twenty-five-aged matched healthy women and 25 women affected by sporadic MS (matched for age, disease duration, EDSS, and white matter lesion load).

Results.

Despite their short disease duration (<5 years), the four sisters showed a significant cortical thinning compared to healthy controls (P=0.003) and sporadic MS (P=0.041) and higher CLs number (P<0.001) and volume (P<0.001) compared to sporadic MS.

Discussion.

Although limited to a single family, our observation is worth of interest since it suggests that familial factors may account for a peculiar involvement of the cortex in MS pathology.

This hypothesis should be further evaluated in a large number of multiplex MS families.

American Psychological Association (APA)

Calabrese, Massimiliano& Seppi, Dario& Cocco, Eleonora& Poretto, Valentina& Rinaldi, Francesca& Perini, Paola…[et al.]. 2012. Cortical Pathology in RRMS : Taking a Cue from Four Sisters. Multiple Sclerosis International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-496586

Modern Language Association (MLA)

Calabrese, Massimiliano…[et al.]. Cortical Pathology in RRMS : Taking a Cue from Four Sisters. Multiple Sclerosis International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-496586

American Medical Association (AMA)

Calabrese, Massimiliano& Seppi, Dario& Cocco, Eleonora& Poretto, Valentina& Rinaldi, Francesca& Perini, Paola…[et al.]. Cortical Pathology in RRMS : Taking a Cue from Four Sisters. Multiple Sclerosis International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-496586

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-496586