The Effect of Dexmedetomidine on Oxidative Stress during Pneumoperitoneum
Joint Authors
Geze, Sükran
Sonmez, Mehmet
Mentese, Ahmet
Cekic, Bahanur
Karahan, S. Caner
Beşir, Ahmet
Ozkan, Gulsum
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
This study was intended to investigate the effect of dexmedetomidine on oxidative stress response in pneumoperitoneum established in rats.
Methods.
Animals were randomized into three groups, group S: with no pneumoperitoneum, group P: with pneumoperitoneum established, and group D: given 100 mcg intraperitoneal dexmedetomidine 30 min before establishment of pneumoperitoneum.
Plasma total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) activity were measured 30 min after conclusion of pneumoperitoneum.
Results.
The mean TOS level was significantly higher in group P than in the other two groups, and the TOS level was significantly higher in group D than in group S (P<0.05).
Plasma TAS level was found to be lower in group P than in the other two groups, and the TAS level was lower in group D than in group S (P<0.05).
Consequently, the OSI was significantly higher in group P than in groups D and S (P<0.05).
Conclusions.
Ischemia-reperfusion phenomenon that occurs during pneumoperitoneum causes oxidative stress and consumption of plasma antioxidants.
Dexmedetomidine decreases oxidative stress caused by pneumoperitoneum and strengthens the antioxidant defense system.
American Psychological Association (APA)
Cekic, Bahanur& Geze, Sükran& Ozkan, Gulsum& Beşir, Ahmet& Sonmez, Mehmet& Karahan, S. Caner…[et al.]. 2014. The Effect of Dexmedetomidine on Oxidative Stress during Pneumoperitoneum. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-496595
Modern Language Association (MLA)
Cekic, Bahanur…[et al.]. The Effect of Dexmedetomidine on Oxidative Stress during Pneumoperitoneum. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-496595
American Medical Association (AMA)
Cekic, Bahanur& Geze, Sükran& Ozkan, Gulsum& Beşir, Ahmet& Sonmez, Mehmet& Karahan, S. Caner…[et al.]. The Effect of Dexmedetomidine on Oxidative Stress during Pneumoperitoneum. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-496595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496595