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Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis
Joint Authors
Das, Asankur Sekhar
Mukherjee, Sandip
Mitra, Chandan
Das, Dolan
Banerjee, Maitrayee
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study was undertaken to find out the ability of black tea extract (BTE) as a suitable alternative of adjunct for calcium supplementation in treating an ovariectomized rat model of early osteoporosis.
Female Wistar rats weighing 140–150 g were divided into four groups consisting of six animals in each group: (A) sham-operated control; (B) bilaterally ovariectomized; (C) bilaterally ovariectomized + BTE; (D) bilaterally ovariectomized + 17β-estradiol.
Results suggest that BTE could promote intestinal absorption of calcium significantly (P<0.01 for duodenum and ileum; and P<0.05 for jejunum).
This was found associated with enhanced activities of two relevant intestinal mucosal enzymes alkaline phosphatase (P<0.01 for duodenum, jejunum, and ileum) and Ca2+ activated ATPase (P<0.01 for duodenum, jejunum, and ileum).
Such BTE-mediated promotion of calcium absorption was coupled with increase in serum estrogen titer (P<0.01) and recovery of all urinary, bone, and serum osteoporotic marker parameters, including bone histological features.
Serum parathyroid hormone level, however, was not altered in these animals (P>0.05).
A comparative study with 17β-estradiol, a well-known adjunct for calcium supplementation, indicated that efficacy of BTE in maintaining skeletal health is close to that of 17β-estradiol.
This study suggests that simultaneous use of BTE is promising as a prospective candidate for adjunctive therapies for calcium supplementation in the early stage of menopausal bone changes.
American Psychological Association (APA)
Das, Asankur Sekhar& Banerjee, Maitrayee& Das, Dolan& Mukherjee, Sandip& Mitra, Chandan. 2013. Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis. Journal of Osteoporosis،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496617
Modern Language Association (MLA)
Das, Asankur Sekhar…[et al.]. Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis. Journal of Osteoporosis No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-496617
American Medical Association (AMA)
Das, Asankur Sekhar& Banerjee, Maitrayee& Das, Dolan& Mukherjee, Sandip& Mitra, Chandan. Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis. Journal of Osteoporosis. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496617