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The Benefits of Humanized Yeast Models to Study Parkinson’s Disease
Joint Authors
Franssens, Vanessa
Vandermeeren, K.
Winderickx, Joris
Verduyckt, Mathias
Bynens, T.
Van den Brande, Jeff
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Over the past decade, the baker’s yeast Saccharomyces cerevisiae has proven to be a useful model system to investigate fundamental questions concerning the pathogenic role of human proteins in neurodegenerative diseases such as Parkinson’s disease (PD).
These so-called humanized yeast models for PD initially focused on α-synuclein, which plays a key role in the etiology of PD.
Upon expression of this human protein in the baker’s yeast Saccharomyces cerevisiae, the events leading to aggregation and the molecular mechanisms that result in cellular toxicity are faithfully reproduced.
More recently, a similar model to study the presumed pathobiology of the α-synuclein interaction partner synphilin-1 has been established.
In this review we will discuss recent advances using these humanized yeast models, pointing to new roles for cell wall integrity signaling, Ca2+ homeostasis, mitophagy, and the cytoskeleton.
American Psychological Association (APA)
Franssens, Vanessa& Bynens, T.& Van den Brande, Jeff& Vandermeeren, K.& Verduyckt, Mathias& Winderickx, Joris. 2013. The Benefits of Humanized Yeast Models to Study Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-496620
Modern Language Association (MLA)
Franssens, Vanessa…[et al.]. The Benefits of Humanized Yeast Models to Study Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-496620
American Medical Association (AMA)
Franssens, Vanessa& Bynens, T.& Van den Brande, Jeff& Vandermeeren, K.& Verduyckt, Mathias& Winderickx, Joris. The Benefits of Humanized Yeast Models to Study Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-496620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496620