Neonatal Thrombocytopenia after Perinatal Asphyxia Treated with Hypothermia : A Retrospective Case Control Study
Joint Authors
Rijken, M.
Razenberg, F.
Smits-Wintjens, V. E. H. J.
Boutaybi, N.
Steggerda, S. J.
Lopriore, Enrico
van Zwet, Erik W.
Source
International Journal of Pediatrics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Our objective was to estimate the effect of therapeutic hypothermia on platelet count in neonates after perinatal asphyxia.
We performed a retrospective case control study of all (near-) term neonates with perinatal asphyxia admitted between 2004 and 2012 to our neonatal intensive care unit.
All neonates treated with therapeutic hypothermia were included in this study (hypothermia group) and compared with a historic control group of neonates with perinatal asphyxia treated before introduction of therapeutic hypothermia (2008).
Primary outcome was thrombocytopenia during the first week after birth.
Thrombocytopenia was found significantly more often in the hypothermia group than in the control group, 80% (43/54) versus 59% (27/46) (P=.02).
The lowest mean platelet count in the hypothermia group and control group was 97×109/L and 125×109/L (P=.06), respectively, and was reached at a mean age of 4.1 days in the hypothermia group and 2.9 days in the control group (P<.001).
The incidence of moderate/severe cerebral hemorrhage was 6% (3/47) in the hypothermia group versus 9% (3/35) in the control group (P=.64).
In conclusion, neonates with perinatal asphyxia treated with therapeutic hypothermia are at increased risk of thrombocytopenia, without increased risk of cerebral hemorrhage.
American Psychological Association (APA)
Boutaybi, N.& Razenberg, F.& Smits-Wintjens, V. E. H. J.& van Zwet, Erik W.& Rijken, M.& Steggerda, S. J.…[et al.]. 2014. Neonatal Thrombocytopenia after Perinatal Asphyxia Treated with Hypothermia : A Retrospective Case Control Study. International Journal of Pediatrics،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-496622
Modern Language Association (MLA)
Boutaybi, N.…[et al.]. Neonatal Thrombocytopenia after Perinatal Asphyxia Treated with Hypothermia : A Retrospective Case Control Study. International Journal of Pediatrics No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-496622
American Medical Association (AMA)
Boutaybi, N.& Razenberg, F.& Smits-Wintjens, V. E. H. J.& van Zwet, Erik W.& Rijken, M.& Steggerda, S. J.…[et al.]. Neonatal Thrombocytopenia after Perinatal Asphyxia Treated with Hypothermia : A Retrospective Case Control Study. International Journal of Pediatrics. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-496622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496622