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HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic Injury
Joint Authors
Schneider, Michelle
Parry, Charles
Neuman, Manuela G.
Nanau, Radu M.
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-11
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The present paper describes possible connections between antiretroviral therapies (ARTs) used to treat human immunodeficiency virus (HIV) infection and adverse drug reactions (ADRs) encountered predominantly in the liver, including hypersensitivity syndrome reactions, as well as throughout the gastrointestinal system, including the pancreas.
Highly active antiretroviral therapy (HAART) has a positive influence on the quality of life and longevity in HIV patients, substantially reducing morbidity and mortality in this population.
However, HAART produces a spectrum of ADRs.
Alcohol consumption can interact with HAART as well as other pharmaceutical agents used for the prevention of opportunistic infections such as pneumonia and tuberculosis.
Other coinfections that occur in HIV, such as hepatitis viruses B or C, cytomegalovirus, or herpes simplex virus, further complicate the etiology of HAART-induced ADRs.
The aspect of liver pathology including liver structure and function has received little attention and deserves further evaluation.
The materials used provide a data-supported approach.
They are based on systematic review and analysis of recently published world literature (MedLine search) and the experience of the authors in the specified topic.
We conclude that therapeutic and drug monitoring of ART, using laboratory identification of phenotypic susceptibilities, drug interactions with other medications, drug interactions with herbal medicines, and alcohol intake might enable a safer use of this medication.
American Psychological Association (APA)
Neuman, Manuela G.& Schneider, Michelle& Nanau, Radu M.& Parry, Charles. 2012. HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic Injury. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-496628
Modern Language Association (MLA)
Neuman, Manuela G.…[et al.]. HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic Injury. International Journal of Hepatology No. 2012 (2012), pp.1-23.
https://search.emarefa.net/detail/BIM-496628
American Medical Association (AMA)
Neuman, Manuela G.& Schneider, Michelle& Nanau, Radu M.& Parry, Charles. HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic Injury. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-496628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496628