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Myeloperoxidase Content is a Marker of Systemic Inflammation in a Chronic Condition : The Example Given by the Periodontal Disease in Rats
Joint Authors
Caliari, Marcelo Vidigal
Pacheco, Cinthia Mara da Fonseca
Queiroz-Junior, Celso Martins
Fonseca, Allyson Henrique
de Francischi, Janetti Nogueira
Klein, André
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The study aimed to evaluate the suitability of myeloperoxidase (MPO) content as a local indicator of chronic inflammation, using the periodontal disease model.
Anesthetized adult male Holtzman rats had their second left maxilar molar tied by a thread for 11 days and were then killed.
Blood samples and photographic images from histopathological inflamed and noninflamed (contralateral) neighboring gingivomucosal specimens were collected for cell counts and MPO level analysis.
Diseased animals were also treated with pharmacological tools such as the anti-inflammatory drug celecoxib or the opioid morphine.
Increased blood neutrophils and local cell numbers characterized diseased animals.
However, local MPO content was increased in inflamed and noninflamed tissues from diseased animals.
Celecoxib and morphine reduced blood neutrophils and bilateral MPO content, but only celecoxib reduced local cell numbers in diseased animals.
It is concluded that MPO content is a good indicator of a systemic rather than a local inflammation in a chronic inflammatory condition.
American Psychological Association (APA)
Queiroz-Junior, Celso Martins& Pacheco, Cinthia Mara da Fonseca& Fonseca, Allyson Henrique& Klein, André& Caliari, Marcelo Vidigal& de Francischi, Janetti Nogueira. 2009. Myeloperoxidase Content is a Marker of Systemic Inflammation in a Chronic Condition : The Example Given by the Periodontal Disease in Rats. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-496638
Modern Language Association (MLA)
Queiroz-Junior, Celso Martins…[et al.]. Myeloperoxidase Content is a Marker of Systemic Inflammation in a Chronic Condition : The Example Given by the Periodontal Disease in Rats. Mediators of Inflammation No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-496638
American Medical Association (AMA)
Queiroz-Junior, Celso Martins& Pacheco, Cinthia Mara da Fonseca& Fonseca, Allyson Henrique& Klein, André& Caliari, Marcelo Vidigal& de Francischi, Janetti Nogueira. Myeloperoxidase Content is a Marker of Systemic Inflammation in a Chronic Condition : The Example Given by the Periodontal Disease in Rats. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-496638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496638