Histological and Clinical Characteristics of Patients with Chronic Hepatitis C and Persistently Normal Alanine Aminotransferase Levels
Joint Authors
Source
Hepatitis Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Patients with chronic hepatitis C virus (HCV) infection and persistently normal alanine aminotransferase (PNALT) are generally described to have mild liver disease.
The aim of this study was to compare clinical and histological features in HCV-infected patients with PNALT and elevated ALT.
Patients presenting to the University of Illinois Medical Center, Chicago, who had biopsy proven HCV, an ALT measurement at the time of liver biopsy, at least one additional ALT measurement over the next 12 months, and liver biopsy slides available for review were identified.
PNALT was defined as ALT ≤ 30 on at least 2 different occasions over 12 months.
Of 1200 patients with HCV, 243 met the study criteria.
13% (32/243) of patients had PNALT while 87% (211/243) had elevated ALT.
Significantly more patients with PNALT had advanced fibrosis (F3 and F4) compared to those with elevated ALT (P=0.007).
There was no significant difference in the histology activity index score as well as mean inflammatory score between the two groups.
In conclusion, in a well-characterized cohort of patients at a tertiary medical center, PNALT did not distinguish patients with mild liver disease.
American Psychological Association (APA)
Roshan, Bakht& Guzman, Grace. 2014. Histological and Clinical Characteristics of Patients with Chronic Hepatitis C and Persistently Normal Alanine Aminotransferase Levels. Hepatitis Research and Treatment،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-496651
Modern Language Association (MLA)
Roshan, Bakht& Guzman, Grace. Histological and Clinical Characteristics of Patients with Chronic Hepatitis C and Persistently Normal Alanine Aminotransferase Levels. Hepatitis Research and Treatment No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-496651
American Medical Association (AMA)
Roshan, Bakht& Guzman, Grace. Histological and Clinical Characteristics of Patients with Chronic Hepatitis C and Persistently Normal Alanine Aminotransferase Levels. Hepatitis Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-496651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496651