Immunotherapy of Cancer : Reprogramming Tumor-Immune Crosstalk
Joint Authors
Wang, Xiang-Yang
Toor, Amir A.
Manjili, Masoud H.
Payne, Kyle K.
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The advancement of cancer immunotherapy faces barriers which limit its efficacy.
These include weak immunogenicity of the tumor, as well as immunosuppressive mechanisms which prevent effective antitumor immune responses.
Recent studies suggest that aberrant expression of cancer testis antigens (CTAs) can generate robust antitumor immune responses, which implicates CTAs as potential targets for immunotherapy.
However, the heterogeneity of tumor cells in the presence and quantity of CTA expression results in tumor escape from CTA-specific immune responses.
Thus, the ability to modulate the tumor cell epigenome to homogenously induce expression of such antigens will likely render the tumor more immunogenic.
Additionally, emerging studies suggest that suppression of antitumor immune responses may be overcome by reprogramming innate and adaptive immune cells.
Therefore, this paper discusses recent studies which address barriers to successful cancer immunotherapy and proposes a strategy of modulation of tumor-immune cell crosstalk to improve responses in carcinoma patients.
American Psychological Association (APA)
Payne, Kyle K.& Toor, Amir A.& Wang, Xiang-Yang& Manjili, Masoud H.. 2012. Immunotherapy of Cancer : Reprogramming Tumor-Immune Crosstalk. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496655
Modern Language Association (MLA)
Payne, Kyle K.…[et al.]. Immunotherapy of Cancer : Reprogramming Tumor-Immune Crosstalk. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-496655
American Medical Association (AMA)
Payne, Kyle K.& Toor, Amir A.& Wang, Xiang-Yang& Manjili, Masoud H.. Immunotherapy of Cancer : Reprogramming Tumor-Immune Crosstalk. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496655