![](/images/graphics-bg.png)
Antifungal Activities of Peptides Derived from Domain 5 of High-Molecular-Weight Kininogen
Joint Authors
Nordahl, Emma Andersson
Malmsten, Martin
Schmidtchen, Artur
Sonesson, Andreas
Source
International Journal of Peptides
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In both immunocompromised and immunocompetent patients, Candida and Malassezia are causing or triggering clinical manifestations such as cutaneous infections and atopic eczema.
The innate immune system provides rapid responses to microbial invaders, without requiring prior stimulation, through a sophisticated system of antimicrobial peptides (AMPs).
High molecular weight kininogen (HMWK) and components of the contact system have previously been reported to bind to Candida and other pathogens, leading to activation of the contact system.
A cutaneous Candida infection is characterized by an accumulation of neutrophils, leading to an inflammatory response and release of enzymatically active substances.
In the present study we demonstrate that antifungal peptide fragments are generated through proteolytic degradation of HMWK.
The recombinant domain 5 (rD5) of HMWK, D5-derived peptides, as well as hydrophobically modified D5-derived peptides efficiently killed Candida and Malassezia.
Furthermore, the antifungal activity of modified peptides was studied at physiological conditions.
Binding of a D5-derived peptide, HKH20 (His479-His498), to the fungal cell membrane was visualized by fluorescence microscopy.
Our data disclose a novel antifungal activity of D5-derived peptides and also show that proteolytic cleavage of HMWK results in fragments exerting antifungal activity.
Of therapeutic interest is that structurally modified peptides show an enhanced antifungal activity.
American Psychological Association (APA)
Sonesson, Andreas& Nordahl, Emma Andersson& Malmsten, Martin& Schmidtchen, Artur. 2011. Antifungal Activities of Peptides Derived from Domain 5 of High-Molecular-Weight Kininogen. International Journal of Peptides،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-496662
Modern Language Association (MLA)
Sonesson, Andreas…[et al.]. Antifungal Activities of Peptides Derived from Domain 5 of High-Molecular-Weight Kininogen. International Journal of Peptides No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-496662
American Medical Association (AMA)
Sonesson, Andreas& Nordahl, Emma Andersson& Malmsten, Martin& Schmidtchen, Artur. Antifungal Activities of Peptides Derived from Domain 5 of High-Molecular-Weight Kininogen. International Journal of Peptides. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-496662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496662