Genome-Wide Association Study of Antiphospholipid Antibodies
Joint Authors
Barmada, Michael M.
Manzi, Susan
Kamboh, M. Ilyas
Clarke, Ann E.
Kao, Amy H.
Ramsey-Goldman, Rosalind
Wang, Xingbin
Demirci, F. Yesim
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The persistent presence of antiphospholipid antibodies (APA) may lead to the development of primary or secondary antiphospholipid syndrome.
Although the genetic basis of APA has been suggested, the identity of the underlying genes is largely unknown.
In this study, we have performed a genome-wide association study (GWAS) in an effort to identify susceptibility loci/genes for three main APA: anticardiolipin antibodies (ACL), lupus anticoagulant (LAC), and anti-β2 glycoprotein I antibodies (anti-β2GPI).
Methods.
DNA samples were genotyped using the Affymetrix 6.0 array containing 906,600 single-nucleotide polymorphisms (SNPs).
Association of SNPs with the antibody status (positive/negative) was tested using logistic regression under the additive model.
Results.
We have identified a number of suggestive novel loci with P Although they do not meet the conservative threshold of genome-wide significance, many of the suggestive loci are potential candidates for the production of APA. We have replicated the previously reported associations of HLA genes and APOH with APA but these were not the top loci. Conclusions. We have identified a number of suggestive novel loci for APA that will stimulate follow-up studies in independent and larger samples to replicate our findings.
American Psychological Association (APA)
Kamboh, M. Ilyas& Wang, Xingbin& Kao, Amy H.& Barmada, Michael M.& Clarke, Ann E.& Ramsey-Goldman, Rosalind…[et al.]. 2013. Genome-Wide Association Study of Antiphospholipid Antibodies. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-496664
Modern Language Association (MLA)
Kamboh, M. Ilyas…[et al.]. Genome-Wide Association Study of Antiphospholipid Antibodies. Autoimmune Diseases No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-496664
American Medical Association (AMA)
Kamboh, M. Ilyas& Wang, Xingbin& Kao, Amy H.& Barmada, Michael M.& Clarke, Ann E.& Ramsey-Goldman, Rosalind…[et al.]. Genome-Wide Association Study of Antiphospholipid Antibodies. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-496664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496664