Progression from Sustained BK Viruria to Sustained BK Viremia with Immunosuppression Reduction Is Not Associated with Changes in the Noncoding Control Region of the BK Virus Genome
Joint Authors
Gaudreault-Keener, Monique
Brennan, Daniel C.
Storch, Gregory A.
Memon, Imran A.
Skelton, Rebecca
Parikh, Bijal A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Changes in the BK virus archetypal noncoding control region (NCCR) have been associated with BK-virus-associated nephropathy (BKVAN).
Whether sustained viremia, a surrogate for BKVAN, is associated with significant changes in the BK-NCCR is unknown.
We performed PCR amplification and sequencing of (1) stored urine and (2) plasma samples from the time of peak viremia from 11 patients with sustained viremia who participated in a 200-patient clinical trial.
The antimetabolite was withdrawn for BK viremia and reduction of the calcineurin inhibitor for sustained BK viremia.
DNA sequencing from the 11 patients with sustained viremia revealed 8 insertions, 16 transversions, 3 deletions, and 17 transitions.
None were deemed significant.
No patient developed clinically evident BKVAN.
Our data support, at a genomic level, the effectiveness of reduction of immunosuppression for prevention of progression from viremia to BKVAN.
American Psychological Association (APA)
Memon, Imran A.& Parikh, Bijal A.& Gaudreault-Keener, Monique& Skelton, Rebecca& Storch, Gregory A.& Brennan, Daniel C.. 2012. Progression from Sustained BK Viruria to Sustained BK Viremia with Immunosuppression Reduction Is Not Associated with Changes in the Noncoding Control Region of the BK Virus Genome. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-496679
Modern Language Association (MLA)
Memon, Imran A.…[et al.]. Progression from Sustained BK Viruria to Sustained BK Viremia with Immunosuppression Reduction Is Not Associated with Changes in the Noncoding Control Region of the BK Virus Genome. Journal of Transplantation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-496679
American Medical Association (AMA)
Memon, Imran A.& Parikh, Bijal A.& Gaudreault-Keener, Monique& Skelton, Rebecca& Storch, Gregory A.& Brennan, Daniel C.. Progression from Sustained BK Viruria to Sustained BK Viremia with Immunosuppression Reduction Is Not Associated with Changes in the Noncoding Control Region of the BK Virus Genome. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-496679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496679