Trans-β-Caryophyllene : An Effective Antileishmanial Compound Found in Commercial Copaiba Oil (Copaifera spp.)
Joint Authors
Ramos, Mônica Freiman de S.
Siani, Antonio C.
Soares, Deivid C.
Saraiva, Elvira M.
Portella, Nathalya A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This study investigated the leishmanicidal activity against Leishmania amazonensis of four commercial oils from Copaifera spp.
named as C1, C2, C3, and C4, the sesquiterpene and diterpene pools obtained from distilling C4, and isolated β-caryophyllene (CAR).
Copaiba oils chemical compositions were analyzed by gas chromatography and correlated with biological activities.
Diterpenes-rich oils C2 and C3 showed antipromastigote activity.
Sesquiterpenes-rich C1 and C4, and isolated CAR presented a dose-dependent activity against intracellular amastigotes, with IC50s of 2.9 µg/mL, 2.3 µg/mL, and 1.3 µg/mL (6.4 µM), respectively.
Based on the highest antiamastigote activity and the low toxicity to the host cells, C4 was steamdistillated to separate pools of sesquiterpenes and diterpenes.
Both pools were less active against L.
amazonensis and more toxic for the macrophages than the whole C4 oil.
The leishmanicidal activity of C3 and C4 oils, as well as C4 fractions and CAR, appears to be independent of nitric oxide production by macrophages.
This study pointed out β-caryophyllene as an effective antileishmanial compound and also to its role as potential chemical marker in copaiba oils or fractions derived thereof, aiming further development of this rainforest raw material for leishmaniasis therapy.
American Psychological Association (APA)
Soares, Deivid C.& Portella, Nathalya A.& Ramos, Mônica Freiman de S.& Siani, Antonio C.& Saraiva, Elvira M.. 2013. Trans-β-Caryophyllene : An Effective Antileishmanial Compound Found in Commercial Copaiba Oil (Copaifera spp.). Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-496685
Modern Language Association (MLA)
Soares, Deivid C.…[et al.]. Trans-β-Caryophyllene : An Effective Antileishmanial Compound Found in Commercial Copaiba Oil (Copaifera spp.). Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-496685
American Medical Association (AMA)
Soares, Deivid C.& Portella, Nathalya A.& Ramos, Mônica Freiman de S.& Siani, Antonio C.& Saraiva, Elvira M.. Trans-β-Caryophyllene : An Effective Antileishmanial Compound Found in Commercial Copaiba Oil (Copaifera spp.). Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-496685
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496685