Porcine Models of Accelerated Coronary Atherosclerosis : Role of Diabetes Mellitus and Hypercholesterolemia
Joint Authors
Wilensky, Robert L.
Hamamdzic, Damir
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Animal models of atherosclerosis have proven to be an invaluable asset in understanding the pathogenesis of the disease.
However, large animal models may be needed in order to assess novel therapeutic approaches to the treatment of atherosclerosis.
Porcine models of coronary and peripheral atherosclerosis offer several advantages over rodent models, including similar anatomical size to humans, as well as genetic expression and development of high-risk atherosclerotic lesions which are similar to humans.
Here we review the four models of porcine atherosclerosis, including the diabetic/hypercholesterolemic model, Rapacz-familial hypercholesterolemia pig, the (PCSK9) gain-of-function mutant pig model, and the Ossabaw miniature pig model of metabolic syndrome.
All four models reliably represent features of human vascular disease.
American Psychological Association (APA)
Hamamdzic, Damir& Wilensky, Robert L.. 2013. Porcine Models of Accelerated Coronary Atherosclerosis : Role of Diabetes Mellitus and Hypercholesterolemia. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-496695
Modern Language Association (MLA)
Hamamdzic, Damir& Wilensky, Robert L.. Porcine Models of Accelerated Coronary Atherosclerosis : Role of Diabetes Mellitus and Hypercholesterolemia. Journal of Diabetes Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-496695
American Medical Association (AMA)
Hamamdzic, Damir& Wilensky, Robert L.. Porcine Models of Accelerated Coronary Atherosclerosis : Role of Diabetes Mellitus and Hypercholesterolemia. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-496695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496695